2009

Lincolnshire Marriott® Resort
Lincolnshire, Illinois
April 30 -May 1, 2009

Meeting Schedule

Thursday, April 30, 2009

Registration, coffee and poster setup, 10:00 AM

Welcome, 11:00 AM

Chemically reactive metabolites in drug discovery and development – Should we care?, 11:10 AM
Thomas Baillie, University of Washington.

Metabolism and DNA binding of carcinogenic tobacco-specific nitrosamines., 11:50 AM
Stephen Hecht, University of Minnesota.

Lunch, poster viewing, and sponsor booths, 12:30 PM

Structure/function analysis of human CYP2A enzymes and the relationship to lung cancer., 2:00 PM
Emily Scott, University of Kansas.

Using a drug metabolism approach to predict response in breast cancer patients., 2:40 PM
James Rae, University of Michigan.

Break, 3:20 PM

Investigation of the metabolism of natural product chemoprevention agents using ultrafiltration mass spectrometry.. 4:00 PM
Richard van Breemen, University of Illinois at Chicago.

Improving warfarin dosing through genetic testing., 4:40 PM
James Burmester, Marshfield Clinic.

Poster session (author available), sponsor booths, and mixer, 5:20 PM

Dinner, 7:30 PM

Friday, May 1, 2009

Business meeting for organizing committee members., 7:30 AM

Coffee., 8:00 AM

PK and PK/PD modeling and simulation in drug discovery., 9:00 AM
Robert Carr, Abbott Laboratories.

Models for incorporating glucuronidation into human pharmacokinetic predictions., 9:35 AM
Hongliang Cai, Pfizer.

Break, 10:10 AM

The effect of losing multiple clearance pathways on drug safety and viability., 10:40 AM
Shelby Anderson, Lilly Research Labs.

Facile hepatic uptake assays to support drug discovery and development., 11:15 AM
Daniel Bow, Abbott Laboratories.

Closing remarks, 11:50 AM

 

Meeting Booklet

If you were unable to attend the last meeting in Lincolnshire, you can download the meeting booklet to read what you missed.

Download the 2009 GLDMDG meeting booklet (PDF)

 

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2008

University Place Conference Center and Hotel at IUPUI
Indianapolis, Indiana
May 1-2, 2008

Meeting Schedule

Thursday, May 1, 2008

Registration, coffee and poster setup, 10:00 AM

Welcome, 11:00 AM

The Evolution of Drug Metabolism: The Gatekeeper for Therapeutics., 11:10 AM
Pat Murphy, Butler University.

Is ABCG2 (Breast Cancer Resistance Protein; BCRP) the Next P-Glycoprotein?, 11:50 AM
Tom Raub, Lilly Research Laboratories.

Lunch, poster viewing, and sponsor booths, 12:30 PM

Nuclear Receptors Mediate the Cross-Talk between Endogenous Pathways and Drug Metabolism., 2:00 PM
Urs Meyer, University of Basel.

Intracrine Regulation of Hepatic Cytochrome P450 Expression., 2:40 PM
Tom Kocarek, Wayne State University.

Break, 3:20 PM

The Chemistry and Biological Consequences of Protein Modification by Reactive Aldehydes.. 3:40 PM
Larry Marnett, Vanderbilt University.

Inter-Species Differences in Carboxylesterase Activity and Expression: Impact on Activation and Pharmacokinetics of Prodrugs., 4:20 PM
Everett Perkins, Lilly Research Laboratories.

Poster session (author available), sponsor booths, and mixer, 5:00 PM

Dinner, 7:00 PM

Friday, May 2, 2008

Business meeting for organizing committee members., 7:30 AM

Coffee., 8:00 AM

Inhibition of Multiple Hepatobiliary Transporters by a Novel Kinase Inhibitor Contributes to Liver Toxicity in Multiple Species., 9:00 AM
Scott Daniels, Pfizer.

Combining Novel Structure-Based and Ligand-Based Computational Approaches to Model Cytochrome P450-Ligand Interaction., 9:35 AM
Marcus Lill, Purdue University.

Break, 10:10 AM

Non-P450 Mediated Metabolism: Carbonyl Reduction., 10:30 AM
Yanbin Lao, Abbott.

Quinoids Formed from Selective Estrogen Receptor Modulators (SERMs): Biological Consequences?, 11:05 AM
Judy Bolton, University of Illinois.

Closing remarks, 11:40 AM

 

Meeting Booklet

Download the 2008 GLDMDG meeting booklet (PDF)

 

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2007

Rackham Building, University of Michigan
Ann Arbor, Michigan
May 3-4, 2007

Meeting Schedule

Thursday, May 3, 2007

Registration, coffee and poster setup, 10:00 AM

Welcome, 11:00 AM
Paul F. Hollenberg, Ph.D., Chair, Dept. of Pharmacology, University of Michigan

Complexity in the Binding of Ligands to Cooperative P450s: 3A4 & 1A2., 11:10 AM
Fred Guengerich, Ph.D., Professor of Biochemistry & Director, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN.

Conformational Flexibility and Heterogeneity of Cytochromes P450., 11:50 AM
Jim Halpert, Ph.D., Professor and Chairman, Department of Pharmacology and Toxicology, Mary Gibbs Jones Distinguished Chair in Environmental Toxicology, Director, NIEHS Center, Interim Director, Sealy Center for Environmental Health and Medicine, The University of Texas Medical Branch, Galveston, TX.

Lunch, poster viewing, and sponsor booths, 12:30 PM

Approaches to Reducing Pharmaceutical Attrition., 2:00 PM
Scott J. Grossman, Ph.D., Vice President, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Lawrenceville, NJ.

Conditional P450 Reductase-Null Mouse Models for Drug Metabolism Research., 2:40 PM
Xinxin Ding, Ph.D., Research Scientist, Human Toxicology and Molecular Epidemiology, New York State Dept. Health, Wadsworth Center, Albany, NY.

Break, 3:20 PM

Regulation of Hepatic Organic Anion Transporters.. 3:40 PM
Mary Vore, Ph.D., Professor and Director, Graduate Center for Toxicology, University of Kentucky, College of Medicine, Lexington, KY.

Pharmacogenetic Variation in Drug Metabolism Alters Smoking Behaviours and the Efficacy of Cessation Treatments, 4:20 PM
Rachel F. Tyndale, M.Sc., Ph.D., Canada Research Chair in Pharmacogenetics Professor, Centre for Addiction and Mental Health & University of Toronto, Toronto, ON.

Poster session (author available), sponsor booths, and mixer, 5:00 PM

Dinner, 7:00 PM

Friday, May 4, 2007

Business meeting for organizing committee members., 7:30 AM

Coffee and poster viewing., 7:30 AM

Funding Patterns in Clinical Toxicology and Pharmacology and What to Expect Now That It Is 5 Years Post-Doubling of the NIH Budget., 9:00 AM
Richard T. Okita, Ph.D., Program Director, NIGMS, Bethesda, MD.

Break., 9:40 AM

Endogenous Glutathione Adducts., 10:00 AM
Ian A. Blair, Ph.D., A.N. Richards Professor and Vice-Chair of Pharmacology, Professor of Chemistry, Director, Center for Cancer Pharmacology, Director, Systems Biology, Institute for Translational Medicine and Therapeutics, Scientific Director, Genomics Institute Proteomics Facility, University of Pennsylvania, Philadelphia, PA.

Leveraging Drug Metabolism and Excretion Data in MIST (Metabolites in Safety Testing) Strategies., 10:40 AM
R. Scott Obach Ph.D., Senior Research Fellow, Pfizer Global Research & Development, Groton, CT.

Closing remarks, 11:20 AM

 

Meeting Booklet

Download the 2007 GLDMDG meeting booklet (PDF)

 

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2006

Brook Lodge Hotel & Conference Resort
Augusta, Michigan
April 27-28, 2006

Meeting Schedule

Thursday, April 27, 2006

Registration, coffee and poster setup, 10:00 AM

Welcome, 11:00 AM
Paul Hollenberg, Ph.D., Chair, Dept. of Pharmacology, University of Michigan, Ann Arbor, MI.

Current Developments and Future Needs in DMPK., 11:15 AM
Gerald Miwa, Ph.D., Vice President, Drug Metabolism & Pharmacokinetics, Millennium Pharmaceuticals Inc., Cambridge, MA.

Why is the Liver Microsomal Cytochrome P450 such a Versatile and Unique Enzyme?, 12:00 PM
Anthony Y. H. Lu, Ph.D., Adjunct Professor, Department of Chemical Biology, College of Pharmacy, Rutgers University, Piscataway, NJ.

Lunch, poster viewing, and sponsor booths, 12:45 PM

Afternoon Introduction., 2:00 PM
Wendell W. Weber, M.D., Ph.D., Professor Emeritus, Dept. of Pharmacology, University of Michigan, Ann Arbor, MI.

Clinical Pharmacogenetics-Pharmacokinetics in New Chemical Entity Development., 2:15 PM
David Katz, Ph.D., Associate Scientific Director, Abbott Laboratories, Abbott Park, IL.

Pharmacogenetics and CYP2C9-mediated Drug Interactions., 3:00 PM
Timothy S. Tracy, Ph.D., Professor and Department Head, Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN.

Break, 3:45 PM

Hepatic Drug Transporters: Expression, Function, and Pharmacogenetics., 4:00 PM
Richard B. Kim M.D., Professor of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.

Can the Rat be used to Predict Human Drug-Drug Interactions?, 4:45 PM
Stephen D. Hall, Ph.D., Professor of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN

Poster session (author available), sponsor booths, and mixer, 5:30 PM

Dinner, 7:00 PM

Friday, April 27, 2006

Business meeting for organizing committee members., 7:30 AM

Introduction., 9:00 AM
Yoichi Osawa, Ph.D., Associate Professor, Dept. of Pharmacology, Univ. of Michigan, Ann Arbor, MI.

New Initiatives in Drug Discovery: The Role for DMPK in the Evolving Interplay of Industry, Academia and Government., 9:15 AM
David D. Christ, Ph.D., Consultant, SNC Partners LLC, Newark, DE.

Break, 10:00 AM

Glucuronidation: The Other Major Metabolic Pathway., 10:15 AM
Steven Wrighton, Ph.D., Senior Research Fellow, Drug Disposition, Lilly Research Labs, Indianapolis, IN.

Innovative Early Clinical Strategies to Rapid Decision-Making., 11:00 AM
Joseph Fleishaker, Ph.D., Executive Director, Translational Medicine, Pfizer Global Research & Development, Ann Arbor, MI.

Closing remarks, 11:45 AM
Joseph Ware, Ph.D., Senior Principal Scientist, Pharmacokinetics, Dynamics, & Metabolism, Pfizer Global Research & Development, Ann Arbor, MI.

 

Meeting Booklet

Download the 2006 GLDMDG meeting booklet (PDF)