Rackham Building, University of Michigan
Ann Arbor, Michigan
May 3-4, 2007
Thursday, May 3, 2007
Registration, Coffee and Poster Setup, 10:00 AM
Welcome, 11:00 AM
Paul Hollenberg, Ph.D., Chair, Dept. of Pharmacology, University of Michigan, Ann Arbor, MI.
Complexity in the Binding of Ligands to Cooperative P450s: 3A4 & 1A2., 11:10 AM
Fred Guengerich, Ph.D., Professor of Biochemistry & Director, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN.
Conformational Flexibility and Heterogeneity of Cytochromes P450., 11:50 AM
Jim Halpert, Ph.D., Professor and Chairman, Department of Pharmacology and Toxicology, Mary Gibbs Jones Distinguished Chair in Environmental Toxicology, Director, NIEHS Center, Interim Director, Sealy Center for Environmental Health and Medicine, The University of Texas Medical Branch, Galveston, TX.
Lunch, Poster Viewing, and Sponsor Booths, 12:30 PM
Approaches to Reducing Pharmaceutical Attrition., 2:00 PM
Scott J. Grossman, Ph.D., Vice President, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Lawrenceville, NJ.
Conditional P450 Reductase-Null Mouse Models for Drug Metabolism Research., 2:40 PM
Xinxin Ding, Ph.D., Research Scientist, Human Toxicology and Molecular Epidemiology, New York State Dept. Health, Wadsworth Center, Albany, NY.
Break, 3:20 PM
Regulation of Hepatic Organic Anion Transporters., 3:40 PM
Mary Vore, Ph.D., Professor and Director, Graduate Center for Toxicology, University of Kentucky, College of Medicine, Lexington, KY.
Pharmacogenetic Variation in Drug Metabolism Alters Smoking Behaviours and the Efficacy of Cessation Treatments., 4:20 PM
Rachel F. Tyndale, M.Sc., Ph.D., Canada Research Chair in Pharmacogenetics Professor, Centre for Addiction and Mental Health & University of Toronto, Toronto, ON.
Poster Session (Author Available), Sponsor Booths, and Mixer, 5:00 PM
Dinner, 7:00 PM
Friday, May 4, 2007
Business Meeting for GLDMDG Committee Members, 7:30 AM
Coffee and Poster Viewings, 8:00 AM
Funding Patterns in Clinical Toxicology and Pharmacology and What to Expect Now That It Is 5 Years Post-Doubling of the NIH Budget., 9:00 AM
Richard T. Okita, Ph.D., Program Director, NIGMS, Bethesda, MD.
Break, 9:40 AM
Endogenous Glutathione Adducts., 10:00 AM
Steven Wrighton, Ph.D., Senior Research Fellow, Drug Disposition, Lilly Research Labs, Indianapolis, IN.
Endogenous Glutathione Adducts., 11:00 AM
Ian A. Blair, Ph.D., A.N. Richards Professor and Vice-Chair of Pharmacology, Professor of Chemistry, Director, Center for Cancer Pharmacology, Director, Systems Biology, Institute for Translational Medicine and Therapeutics, Scientific Director, Genomics Institute Proteomics Facility, University of Pennsylvania, Philadelphia, PA.
Leveraging Drug Metabolism and Excretion Data in MIST (Metabolites in Safety Testing) Strategies., 10:40 AM
R. Scott Obach Ph.D., Senior Research Fellow, Pfizer Global Research & Development, Groton, CT.
Closing Remarks, 11:20 AM