2015 Meeting

Michigan Union, University of Michigan

Ann Arbor, Michigan
May 7-8, 2015
Meeting Booklet

Thursday, May 7, 2015

Registration, Continental Breakfast, Poster Setup, and Sponsor Booth Setup, 10:00 AM

Welcome, 11:00 AM

P450s and Drug Metabolism: Yesterday, Today, and Forever, 11:10 AM
Paul Hollenberg, Ph.D., Professor, Department of Pharmacology, University of Michigan

Oxidations of Endogenous Substrates by Human P450s: Lessons for Mechanisms of Metabolism of Drugs, 11:50 AM
F. Peter Guengerich, Ph.D., Tadashi Inagami Professor of Biochemistry, Department of Biochemistry, Vanderbilt University

Lunch, Students and Postdocs Network with Industry Scientists, Poster Viewing, and Sponsor Booths, 12:30 PM

Vitamin D as a Source of Inter-Individual Variability in the Regulation and Expression of Intestinal CYP3A4, 2:00 PM
Kenneth Thummel, Ph.D., Professor and Chair, Department of Pharmaceutics, University of Washington

Half-life Extension Strategies for Biotherapeutics in Drug Discovery, 2:40 PM
Larry Wienkers, Ph.D., Executive Director, PKDM, Amgen

Break, 3:20 PM

Development, Characterization and Application of a Humanized PEPT1 Mouse Model for Studying Peptide/Mimetic Absorption and Pharmacokinetics, 3:40 PM
David E, Smith, Ph.D., John G. Wagner Collegiate Professor, Department of Pharmaceutical Sciences, University of Michigan

Aldehyde Oxidase and Donor Variability: Is Estimating Human Clearance Possible?, 4:20 PM
Matthew Hutzler, Ph.D., Director, In Vitro Metabolism, Quintiles

Poster Session (Author Available), Sponsor Booths, and Mixer, 5:00 PM

Dinner, 7:00 PM  

Friday, May 8, 2015

GLDMDG Business Meeting and Sponsor Booth Setup, 7:30 AM

Continental Breakfast and Poster Viewing, 7:30 AM

Quantitative Systems Pharmacology in PKPD and Beyond, 8:45 AM
Saroja Ramanujan Ph.D., Sr. Scientist, Group Lead, Translational & Systems Pharmacology, Genentech

In Vitro DMPK Screening to Accelerate Drug Discovery, 9:25 AM
Kelly Desino, Ph.D., Group Leader, Drug Metabolism & Pharmacokinetics, AbbVie

Break, 10:05 AM

Application of the Humanized Mouse Liver Model: A Preclinical Model of Human Drug Disposition and Toxicity?, 10:25 AM
Yingying Guo, Senior Research Scientist, Drug Disposition, Lilly Research Labs, Indianapolis

Molecular Dynamics of Human CYP2D6 Provides Insights Into Structure, Function, and Susceptibility to Inactivation of Polymorphic Variants of CYP2D6, 11:05 AM
Kyle F. Sunden, Student, Department of Chemistry, Kalamazoo College

Influence of Carboxylesterase 1 Genetic Polymorphisms on the Metabolism of Oseltamivir and Methylphenidate, 11:20 AM
Jian Shi, Postdoc, Department of Clinical, Social, and Administrative Sciences, College of Pharmacy, University of Michigan

Closing Remarks, 11:35 AM