Great Lakes Drug Metabolism and Disposition Group

2010 Meeting

Schedule &
Meeting Booklet


2010 Meeting

St. Louis, Missouri (Daniel Schwen/Wikimedia Commons, Creative Commons)

St. Louis, Missouri (Daniel Schwen/Wikimedia Commons, Creative Commons)

Marriott West

St. Louis, Missouri
May 6-7, 2010
Meeting Booklet


Thursday, May 6, 2010

Registration, Coffee and Poster Setup, 10:00 AM

Welcome, 11:00 AM

Multiple Transport Systems in the BBB: Impact on CNS Drug Delivery., 11:10 AM
William F. Elmquist, Professor and Department Head, Department of Pharmaceutics, College of Pharmacy, University of Minnesota.

Probing Mechanisms of Inter-Individual Susceptibility to Toxicants with Population-Based Experimental Approaches., 11:50 AM
Ivan Rusyn, Associate Professor, Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill.

Lunch, Poster Viewing, and Sponsor Booths, 12:30 PM

Minimally and Noninvasive Clinical CYP3A Phenotyping., 2:00 PM
Evan Kharasch, Director, Division of Clinical and Translational, Research Professor of Anesthesiology, Washington University at St. Louis.

Drug Biotransformation in Children: Role of Ontogeny, Pharmacogenetics and Developmental Context., 2:40 PM
J. Steven Leeder, Professor of Pediatrics and Pharmacology, University of Missouri, Kansas City.

Break, 3:20 PM

Drug and Disease Model Based Biologic Drug Development., 3:40 PM
Jenny Chien, Research Advisor, Lilly Research Labs, Eli Lilly & Co.

Quantification of Gemcitabine-DNA Adducts in Patient Blood, a Novel Biomarker., 4:20 PM
Enaksha Wickremsinhe, Principle Research Scientist, Drug Disposition, Eli Lilly & Co.

Poster Session (Author Available), Sponsor Booths, and Mixer, 5:00 PM

Dinner, 7:30 PM  


Friday, May 7, 2010

GLDMDG Business Meeting, 7:00 AM

Preclinical to Clinical Translation of Tasocitinib (CP-690,550), a JAK Inhibitor, in Rheumatoid Arthritis., 9:00 AM
Martin Dowty, Senior Principal Scientist, Pharmacokinetics Dynamics and Metabolism (PDM), Pfizer

Enabling Compound Progression with Improved Drug-Drug Interaction Predictions., 9:35 AM
Mohamad Shebley, Senior Scientist, Abbott Laboratories.

Break, 10:10 AM

Investigation of Metabolism-Mediated Toxicity in Early Development., 10:40 AM
William Humphreys, Bristol-Myers Squibb.

Probing the Recognition Signal for Ubiquitination of Suicide-Inactivated Neuronal Nitric Oxide Synthase with a C331A Mutant of the Enzyme., 11:15 AM
Kelly M. Clapp, Graduate Student, University of Michigan.

Effects of Valproic Acid on Organic Acid Metabolism in Children: A Metabolic Profiling Study., 11:40 AM
Kristin E. Price, Post-Doc, Children Mercy Hospital.

Closing Remarks, 12:05 PM