Great Lakes Drug Metabolism and Disposition Group

2019 Meeting

Meeting Schedule and Other Information


2019 Meeting

University of Michigan North Campus Research Complex (NCRC)

Ann Arbor, Michigan
May 9-10, 2019
Meeting Booklet

Thursday, 9 May 2019

Registration, Poster Setup, and Sponsor Booth Setup, 10:00 AM

Welcome, 11:00 AM
Paul F Hollenberg, Ph.D., Department of Pharmacology, University of Michigan, Ann Arbor, MI

Quo Vadis, Cytochrome P450? Successes, Advances, and Future Research, 11:10 AM
Frederick P Guengerich, Ph.D., Tadashi Inagami Professor of Biochemistry, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN

Hepatic P450 Degradation: Physiological, Pathological and Therapeutic Relevance, 11:50 AM
Maria Almira Correia, Ph.D., Professor of Pharmacology, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA

Lunch, Students and Postdocs Network with Industry Scientists, View Posters, and Visit Sponsor Booths, 12:30 PM

Application Of Intestinal Organoid Cell Culture in Drug Metabolism and Toxicity Studies, 2:00 PM
Shujuan Chen, Ph.D., DABT, Assistant Professor, University of California, San Diego, La Jolla, CA

Challenges and Recent Progress Toward In Vitro-to-In Vivo Extrapolation of Transporter-Mediated Hepatic Clearance, 2:40 PM
Bridget Morse, Pharm.D., Ph.D., Senior Research Scientist, Eli Lilly, Indianapolis, IN

Break, 3:20 PM

Transporter Endogenous Biomarkers for Prediction of Clinical Drug-Drug Interactions, 3:40 PM
Kenta Yoshida, Ph.D., Scientist, Clinical Pharmacology, Genentech Research and Early Development, South San Francisco, CA

IVIVE-PBPK Modeling of Heterogeneous Drug Penetration into Human Brain Tumors, 4:20 PM
Jing Li, Ph.D., Associate Professor, Department of Oncology, Wayne State University School of Medicine, Detroit, MI

Poster Session (Author Available), Sponsor Booths, and Mixer, 5:00 PM

Dinner, 7:30 PM


Friday, 10 May 2019

GLDMDG Business Meeting, 7:30 AM

Continental Breakfast, Poster Viewing and Sponsor Booth Setup, 7:30 AM

Lessons from Targeted Covalent Bruton’s Tyrosine Kinase Inhibitors, Acalabrutinib and its Major Metabolite: Disposition of a Unique, Low Reactivity, High Selectivity Warhead, 9:00 AM
Terry Podoll, Ph.D., Principal Consultant, Increased Value Pharmaceutical Outsourcing, LLC, Seattle, WA

Discovery and Development of Venetoclax from the DMPK Perspective, 9:40 AM
Dan Bow, Ph.D., Senior Principal Research Scientist, DMPK-BA Development Sciences, AbbVie, North Chicago, IL

Break, 10:20 AM

Drug Metabolism by Gut Bacteria, 10:40 AM
Hyun Young Jeong, Pharm.D., Ph.D., Professor of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL

Contribution of Organic Cation Transporter 3 (OCT3) to Doxorubicin-Induced Cardiotoxicity, 11:20 AM
Kevin M. Huang, B.S., Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, Student Abstract Award Winner

Insight of Cytochrome P450 24A1 and Adrenodoxin Interaction as Modulated by Carbon-25 Hydroxylation of Vitamin-D Ligand, 11:35 AM
Amit Kumar, Ph.D., Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY, Postdoc Abstract Award Winner

Closing Remarks, 11:50 AM