Great Lakes Drug Metabolism and Disposition Group

2018 Meeting

Meeting Schedule and Other Information


2018 Meeting

Skyline Indianapolis, Indiana ( Jimmy Baikovicius /Flickr, Creative Commons)

Skyline Indianapolis, Indiana (Jimmy Baikovicius/Flickr, Creative Commons)

Sheraton Indianapolis City Centre Hotel

Indianapolis, Indiana
May 10-11, 2018
Meeting Booklet

Thursday, May 10, 2018

Registration, Poster Setup, and Sponsor Booth Setup, 10:00 AM

Welcome, 11:00 AM

Applications of Translational Science in Drug Development and Regulatory Agencies – Challenges and Opportunities, 11:10 AM
Larry Lesko, Ph.D., Professor of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL

The Impact of Cellular Binding Proteins on Metabolic Enzyme Activity, 11:50 AM
Nina Issoherranen, Ph.D., Professor and Vice-Chair of Pharmaceutics, University of Washington, Seattle, WA

Lunch, Students and Postdocs Network with Industry Scientists, View Posters, and Visit Sponsor Booths, 12:30 PM

Protein Structure Based Approaches for Reducing Potential P450 Drug-Drug Interactions, 2:00 PM
Eric Johnson, Ph.D., Professor of Molecular Medicine, Scripps Research Institute, La Jolla, CA

Allosteric Mechanism of Drug-Drug Interactions Mediated by Human Cytochrome P450 CYP3A4, 2:40 PM
Ilia Denisov, Ph.D., Senior Research Scientist, Department of Biochemistry. University of Illinois, Urbana, IL

Break, 3:20 PM

Projection of Plasma Metabolite-to-Parent Drug Ratio in Human, 3:40 PM
Scott Obach, Ph.D., Senior Research Fellow, Pharmacokinetics, Dynamics, & Drug Metabolism Department, Pfizer Inc., Groton, CT

Drug Discovery Challenges for Developing a Treatment for Glioblastoma, 4:20 PM
Laurent Salphati, Pharm.D., Ph.D. Principal Scientist, Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA

Poster Session (Author Available), Sponsor Booths, and Mixer, 5:00 PM

Dinner and Special Presentation, 7:00 PM


Friday, May 11, 2018

GLDMDG Business Meeting, 7:30 AM

Continental Breakfast, Poster Viewing and Sponsor Booth Setup, 7:30 AM

Solute Carriers as Modulators of Chemotherapy Toxicity, 9:00 AM
Alex Sparreboom, Ph.D., Professor of Pharmaceutics, The Ohio State University, Columbus, OH

The Dose Makes the Drug:  Strategies to Assess and Improve the Probability of Success for Small Molecule and Antibody Drug Candidates, 9:40 AM
Cory Kalvas, Ph.D., Senior Principal Research Scientist, AbbVie, Chicago, IL

Break, 10:20 AM

Non-CYP Metabolism: Lost in Translation, 10:40 AM
Michael Mohutsky, Ph.D., Principal Research Scientist, Eli Lilly and Co., Indianapolis, IN

Differential Microbiota in the Gut Modulates Susceptibility to Acetaminophen-Induced Hepatotoxicity in C57BL/6 Mice, 11:20 AM
Student Abstract Award Winner: Sungjoon Cho, Graduate Student, University of Illinois at Chicago

Physiologically-Based Pharmacokinetic Model Incorporating Extrahepatic Glucuronidation Predicts Integrase Inhibitor Pharmacokinetics, 11:35 AM
Postdoc Abstract Award Winner: Stephanie Liu, Pharm.D., Clinical Pharmacology Fellow, Indiana University School of Medicine

Closing Remarks, 11:50 AM

Eli Lilly Tour for Students and Postdocs, 12:15 PM