2025 Meeting

Purdue Memorial Union, Purdue University

West Lafayette, Indiana
May 8 and 9, 2025
Meeting Booklet

Thursday, May 8th

Check in, coffee, poster setup, and sponsor booth setup, 10:00 AM

Welcome, 11:00 AM
Hyunyoung Jeong, Ph.D., Dept. of Industrial & Physical Pharmacy, Purdue University, West Lafayette, IN

Diving into the weeds: Cannabinoid (THC and CBD) disposition, DDI and PBPK modeling and simulation, 11:10 AM
Jashvant Unadkat, Ph.D., Professor and Chair, Dept. of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA

CYP1B1 and its regulation in HSC activation and liver fibrosis, 11:50 AM
Wen Xie, M.D., Ph.D., Professor, Joseph Koslow Endowed Chair of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA

Lunch, view posters, and visit sponsor booths. Student and postdoc networking event with industry scientists and major benefactor presentations, 12:30 PM

Biotransformation of cannabinoids and endocannabinoids by human cytochrome P450 enzymes, 2:00 PM
Aditi Das, Ph.D., Professor, School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA

Cell painting and MPS integration: Patient iPSC liver organoids for predictive toxicology, 2:40 PM
Jonathan Sexton, Ph.D., Assistant Professor of Internal Medicine, Medical School, and Assistant Professor of Medicinal Chemistry, University of Michigan, Ann Arbor, MI

Break, 3:20 PM

Post-translational modifications of the human apical sodium-dependent bile acid transporter, hASBT, 3:40 PM
Lindsay Czuba, Ph.D., Assistant Professor, Pharmaceutical Sciences Dept., College of Pharmacy, University of Kentucky, Lexington, KY

Neuropathy and transporter interaction of ADC payloads, 4:20 PM
Kevin Huang, Ph.D., Research Scientist, The Ohio State University, Columbus, OH

Poster session (authors available), sponsor booths, and mixer. 5:00 PM
Authors at odd numbered posters (5:00-6:00 PM). Authors at even numbered posters (6:00-7:00 PM).

Dinner, 7:30 PM

Friday, May 9th

GLDMDG business meeting, 7:45 AM

Continental breakfast, poster viewing and sponsor booth setup, 7:45 AM

Vendor Presentations, 8:150 AM

• Evaluation of CYP- and non-CYP enzyme-based metabolism in preclinical reaction phenotyping studies – A CRO perspective, 8:15 AM
  Tina Mueller Ph.D., Scientific Advisor, ADMET Services, BioIVT, Vendor presentation

• Application of targeted mass spectrometry imaging in pharmaceutical industry, 8:30 AM
  Alena Joignant, Ph.D., Senior Scientist I, AbbVie Inc., Vendor presentation (on behalf of Agilent Technologies)

PBPK: What is the confidence of your prediction?, 9:00 AM
Jialin Mao, Ph.D., Distinguished Scientist, Genentech, South San Francisco, CA

Evaluation and prediction of small molecule drug-drug interactions due to gastric emptying delay, 9:40 AM
Bridget Morse, Ph.D., Senior Director, Lilly, Indianapolis, IN

Break, 10:20 AM

Predicting clearance using advanced human hepatocyte models for metabolically stable compounds, 10:40 AM
David Kukla, Ph.D., Senior Research Scientist I, AbbVie, North Chicago, IL

Gut bacterial metabolite 3-phenylpropionic acid attenuates acetaminophen-induced cytotoxicity in primary mouse hepatocytes by inhibiting cytochrome P450 2E1 expression, 11:20 AM
Pei-Ru Jin, B.S., M.S., Purdue University, West Lafayette, IN, Student abstract award winner presentation

Preventing vincristine-induced neurotoxicity by nilotinib: effects on neuronal transport and anti-leukemic efficacy, 11:35 AM
Yue Xu Ph.D., The Ohio State University, Columbus, OH, Post-doc abstract award winner presentation

Closing remarks, 11:50 AM